IMR Press / FBL / Volume 9 / Issue 2 / DOI: 10.2741/1351

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Transverse Myelitis: pathogenesis, diagnosis and treatment
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1 Department of Neurology, Johns Hopkins Transverse Myelitis Center, 600 N. Wolfe Street Pathology 627C, Baltimore MD 21287-6965
2 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Osler 320, 600 N. Wolfe Street, Baltimore, MD 21287-5371
Academic Editor:Alireza Minagar
Front. Biosci. (Landmark Ed) 2004, 9(2), 1483–1499; https://doi.org/10.2741/1351
Published: 1 May 2004
(This article belongs to the Special Issue Inflammatory disorders of the nervous system)
Abstract

Transverse Myelitis (TM) is a clinical syndrome in which an immune-mediated process causes neural injury to the spinal cord, resulting in varying degrees of weakness, sensory alterations and autonomic dysfunction. TM may exist as part of a multi-focal CNS disease (e.g. MS), multi-systemic disease (e.g. systemic lupus erythematosus), or as an isolated, idiopathic entity. In this article, we will summarize recent classification and diagnostic schemes (1), which provide a framework for the acute management of patients with TM. Additionally, we will review current concepts on the natural history, immunopathogenesis and treatment strategies for patients with TM.

Keywords
Transverse myelopathy
Transverse myelitis
Neuroimmunologic disorders
Interleukin-6
Review
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