Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
, Leszek Kaczmarek 11 Laboratory of Molecular Neurobiology, The Nencki Institute, 02-093 Warsaw, Pasteura 3, Poland
2 Department of Genetics, Faculty of Biology, University of Warmia and Mazury, Olsztyn 10-719, ul. Plac Lodzki 3, Poland
Abstract
Activator protein-1 (AP-1) is a transcription factor involved in many aspects of the brain physiology and pathophysiology. In spite of strong engagement in a transcriptional regulation of the brain gene expression, only a few, if any, downstream AP-1 targets have unequivocally been identified so far. In the review we discuss only the best characterized AP-1 target genes in the brain, and we highlight the shortages of our understanding of AP-1 action in the central nervous system as well as indicate what could be done to ameliorate the situation.
Keywords
- Gene Regulation
- Gene expression
- TRE
- Jun
- Fos
- Transcription
- EMSA
- Review