IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/klimatcheva

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Lentiviral vectors and gene therapy
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1 Departments of Medicine and Microbiology & Immunology, University of Rochester Cancer Center, NY 14642, USA
Academic Editors:Joseph Rosenblatt, Vicente Planelles
Front. Biosci. (Landmark Ed) 1999, 4(4), 481–496; https://doi.org/10.2741/klimatcheva
Published: 1 June 1999
(This article belongs to the Special Issue Gene therapy approaches to HIV-1 Infection)
Abstract

Gene therapy is a novel method under investigation for the treatment of genetic, metabolic and neurologic diseases, cancer and AIDS. The primary goal of gene therapy is to deliver a specific gene to a pre-determined target cell, and to direct expression of such a gene in a manner which will result in a therapeutic effect. Retroviral vectors have the ability to integrate in the host cell DNA irreversibly and therefore, are suitable vectors for permanent genetic modification of cells. Retrovirus-mediated gene transfer has been limited, however, by the inability of onco-retroviruses to productively infect non-dividing cells. Lentiviruses are unique among retroviruses because of their ability to infect target cells independently of their proliferation status. This chapter presents an up-to-date description of available lentiviral vectors, including vector design, applications to disease treatment and safety considerations. In addition, general aspects of the biology of lentiviruses with relevance to vector development will be discussed.

Keywords
HIV
Lentivirus
Vector
Gene therapy
SIV
FIV
Retrovirus
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