IMR Press / FBL / Volume 26 / Issue 8 / DOI: 10.52586/4951
Open Access Commentary
Challenges at the host-arthropod-coronavirus interface and COVID-19: a One Health approach
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1 SaBio, Instituto de Investigación en Recursos Cinegéticos (Research Institute of Hunting Resources) IREC-CSIC-UCLM-JCCM, 13005 Ciudad Real, Spain
2 Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
*Correspondence: (José de la Fuente)
Front. Biosci. (Landmark Ed) 2021, 26(8), 379–386;
Submitted: 10 June 2021 | Revised: 19 July 2021 | Accepted: 21 July 2021 | Published: 30 August 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (

Background: The world faces the challenge posed by the interaction between hosts and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) with potential role for arthropod vectors, and the effect of SARS-CoV-2 variants on acquired immunity, vaccine efficacy and coronavirus disease-19 (COVID-19) pandemic control. Proposal: The characterization of the role played by animal hosts and host-virus interactions is essential to address this challenge. Zoonotic (animal-to-human) and reverse zoonotic (human-to-animal) routes may be involved in virus transmission with a possible still unconfirmed role for arthropod vectors. Herein we propose to consider the risks posed by the possible role of arthropod vectors in COVID-19 and that immunity against SARS-CoV-2 may increase the risk for zoonotic virus transmission. These risks should be considered when evaluating vaccine efficacy and monitoring animal SARS-CoV-2 variants. Conclusion: Virus surveillance, epidemiology, sequencing and evaluation of susceptibility to antibodies and other protective immune mechanisms from vaccinated individuals should be improved. A One Health approach such as the one applied by our group SaBio is necessary for a more effective control of COVID-19 and prevention of future pandemics.

Immune response
Virus variants
Fig. 1.
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