IMR Press / FBL / Volume 26 / Issue 3 / DOI: 10.2741/4907

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Nanog promotes stem-like traits of glioblastoma cells
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1 Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology, Military of Education of China, Chongqing, China
2 Department of Pathology, General hospital of southern theatre command, People’s Liberation Army, Guangzhou, China
Send correspondence to: Deyu Guo, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology, Military of Education of China, Chongqing, China, Tel: 18083010689, E-mail: 2580685422@qq.com
Front. Biosci. (Landmark Ed) 2021, 26(3), 552–565; https://doi.org/10.2741/4907
Published: 1 October 2020
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor progrnosis and a high recurrence rate after surgery. To this end, we examined the role of Nanog that is highly expressed in this tumor. NANOG is a transcription factor involved in the pluripotency of embryonic stem cells (ESCs) and the induction of malignancy in cancer stem-like cells (CSCs). Bioinformatic analysis revealed that NANOG may be associated with the development of stem-like traits in GBM. Forced expression of NANOG markedly increased the expression of cancer stem cell markers and promoted the sphere formation and migration of GBM cells. Nanog enhanced the expression of SHH which is required for the maintenance of the positive feedback loop of Hedgehog signaling pathway. Treatment of GBM cells with SANT-1 and GANT61 significantly reduced the tumor progression. These data support a view that reduction of Nanog might have therapeutic benefits in GBM.

Keywords
Glioblastoma
Nanog
Stemness
migration
invasion
Hedgehog signaling pathway
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