IMR Press / FBL / Volume 24 / Issue 2 / DOI: 10.2741/4723

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Lactate as a signaling molecule: Journey from dead end product of glycolysis to tumor survival
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1 Biochemistry Laboratory, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar, 470003, Madhya Pradesh, India
2 Insect Immunity Lab, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar-470003 (M.P.), India
3 Biochemistry and Molecular Biology Lab, Department of Zoology, Banaras Hindu University, Varanasi,221005, Uttar Pradesh, India
*Correspondence: rkkoiri@gmail.com (Raj Kumar Koiri)
Front. Biosci. (Landmark Ed) 2019, 24(2), 366–381; https://doi.org/10.2741/4723
Published: 1 January 2019
(This article belongs to the Special Issue Frontiers in modern biology)
Abstract

Global metabolism of cancers exhibits a peculiar phenotype that is lactate acidosis (high lactate with acidic pH) in tumor microenvironment. Why tumor microenvironment becomes so responsive towards lactate is still not clear. In this review we have discussed lactate generation and recycling either exogenously, directly or indirectly by cancer cells via some transporters. Tumor cells in hypoxia use glucose rapidly and produce lactate while cells which have profuse oxygen supply take up lactate and use it for energy production which is referred as lactate shuttling between tumor cells. Escaping immune evasion which is also an emerging hallmark of cancer cells has also been discussed in this review with respect of lactate acidosis.

Keywords
Cancer metabolism
Lactate
LDH-A
MCTs
Monocarboxylate transporters
p53
PFKFB3
Review
Figures
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