IMR Press / FBL / Volume 10 / Issue 3 / DOI: 10.2741/1715

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Platelet aggregation: involvement of thrombin and fibrin(ogen)
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1 Department of Haematology, University Medical Centre Utrecht, The Netherlands

Academic Editor: Arthur Chu

Front. Biosci. (Landmark Ed) 2005, 10(3), 2504–2517; https://doi.org/10.2741/1715
Published: 1 September 2005
(This article belongs to the Special Issue Blood coagulation, inflammation, and thrombosis)
Abstract

Platelets play a key role in hemostasis and thrombosis. The formation of a platelet plug is accompanied by the generation of thrombin, which results in the generation of fibrin required for stabilization of the platelet plug. Platelet plug formation and coagulation are closely linked processes. Thrombin is a potent platelet activator, which proceeds through proteolysis of the protease activated receptors (PARs). Furthermore, thrombin binds glycoprotein Ib(alpha), which amplifies platelet activation by accelerating PAR-1 activation, and possibly also by direct signaling events through glycoprotein Ib(alpha). Moreover, thrombin's specificity towards other substrates changes after binding glycoprotein Ib(alpha). Fibrinogen and fibrin, the end product of the coagulation cascade, are also involved in platelet aggregation. Both fibrinogen and fibrin bind the integrin alpha(IIb)beta(3), and another fibrin receptor involved in platelet aggregation has been postulated. This review will discuss the role of thrombin and fibrin(ogen) in platelet functioning, and will highlight pathways at the crossroad of coagulation and platelet functioning, which are potential targets for antithrombotic therapy.

Keywords
Thrombin
Fibrinogen
Fibrin
Platelet
Glycoprotein Ib
Protease-Activated Receptor
Review
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