Dear Colleagues,

Conduction system pacing (CSP) and device-based therapies represent two new advances in the field of modern cardiac electrophysiology. Moving beyond conventional right ventricular pacing, these two emerging CSP techniques—His-bundle pacing (HBP) and left bundle branch area pacing (LBBAP)—offer a more physiological approach to ventricular activation, with promising benefits for heart failure management, arrhythmia prevention, and long-term outcomes. In parallel, innovations in cardiac resynchronization therapy (CRT), leadless systems, and defibrillator technologies are reshaping clinical practice, supported by advances in imaging, navigation, and artificial intelligence.

This Special Issue aims to bring together cutting-edge research, original studies, and expert reviews on CSP and device-based strategies, bridging the gap between technological innovation and real-world clinical practice. Topics include novel pacing algorithms, comparative effectiveness of CSP versus CRT, integration of AI-driven decision support, device safety and reliability, and long-term patient outcomes. This Special issue will review the roles of these multidisciplinary interventions, to define current standards, identify unmet needs, and set the stage for the next decade of progress and innovation in the field of cardiac pacing and device therapy.

Dr. Michael D. Spartalis
Guest Editor