Dear Colleagues,

Medical specialization has improved our understanding of heart failure (HF), diabetes mellitus (DM), and dyslipidemia, but often leads to fragmented care for patients who must face these conditions together. With nearly half a billion people worldwide living with diabetes which doubles cardiovascular risk, and dyslipidemia which increases disease progression, integrating care is critical. Managing these conditions separately results in excessive use of medication and increases confusion.

This themed issue calls for cohesive, patient-centered cardiometabolic health strategies. We seek submissions exploring cellular connections such as insulin resistance and inflammation, studies on the interplay between DM and HF, lipid roles beyond LDL-C, and integrated clinical approaches involving multidisciplinary teams. Protocols uniting cardiologists, endocrinologists, and primary care are essential to achieve better clinical outcomes in these patients. We therefore welcome insights into team-based models, training, and system-wide collaboration.

Patient engagement remains vital, therefore articles on shared decision-making, outcome tracking, digital tools, advocacy perspectives, and psychological impacts are encouraged. Innovative therapies such as SGLT2 inhibitors and GLP-1 receptor agonists have shown promise in patients with DM and HF. Therefore, it is important to report real-world data, treatment combinations, and strategies to implement these interventions in clinical practice.

Addressing social determinants, disparities, and urban challenges is crucial. We invite research on combined risk factors, food security, community efforts, and policy initiatives. Collaboration among funders, academia, and industry, international partnerships, and advanced methodologies will accelerate progress in this field.

This issue promotes an integrated approach to chronic disease management, aiming to improve outcomes for millions by moving past isolated, piecemeal care.

Prof. Dr. Krishnaswami Vijayaraghavan
Guest Editor