Dear Colleagues,

Cardiovascular disease remains the predominant cause of mortality worldwide despite substantial advances in therapeutic strategies. Consequently, there is an urgent demand for developing novel therapeutic strategies for repairing and restoring damaged myocardium after cardiovascular diseases. Advancements in molecular cardiology, including targeted gene editing, stem cell therapy, tissue engineering, omics technologies, and translational research, alongside the integration of artificial intelligence and machine learning, have uncovered a broad spectrum of novel signaling pathways and molecular targets involved in cardiac injury. Cardiac injury involves adverse responses, including endothelial dysfunction, immune cell activation, inflammation, fibrotic remodeling, angiogenesis, tissue regeneration, and metabolic disorders, which lead to chronic cardiovascular complications.

This special issue, “Molecular Targets and Protective Strategies in Cardiovascular Injury”, aims to highlight current progress and innovative approaches in identifying therapeutic targets and developing cardioprotective strategies. We welcome original research, reviews, and translational studies exploring molecular and cellular mechanisms, novel biomarkers, pharmacological and genetic interventions, and cutting-edge technologies that promote myocardial protection and functional recovery after cardiovascular injury. Through this collection, we hope to foster a deeper understanding that will inevitably lead to significant advancements in precision cardiovascular medicine for improving patient outcomes and decreasing the global burden of cardiovascular disease.

Dr. Anindita Das
Guest Editor