Diabetic Cardiomyopathy: From Mechanisms to Therapy
Submission Deadline: 15 Sep 2026
Guest Editor
Djamel Lebeche PhD, FAHA, FACC
Department of Physiology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA
Interests: pathobiology of diabetes-induced heart failure; functional genemics of cardiometabolism; diabetes drug discovery
Special Issue in IMR Press journals
Special Issue in Recent Advances in Diabetic Cardiomyopathy
Special Issue Information
Dear Colleagues,
Diabetic cardiomyopathy (DCM) represents a distinct clinical entity characterized by structural and functional abnormalities of the myocardium in patients with diabetes, independent of coronary artery disease or hypertension. As the global burden of diabetes continues to rise, understanding the pathophysiological mechanisms underlying DCM has now become an urgent matter. This special issue aims to provide a comprehensive overview of the latest advances in the molecular, cellular, and metabolic pathways contributing to DCM, as well as emerging diagnostic tools and therapeutic strategies. By bringing together cutting-edge research and expert reviews, we hope to foster interdisciplinary dialogue and accelerate the translation of basic science into clinical practice.
Proposed Topics to be Addressed:
- Molecular mechanisms of myocardial fibrosis and inflammation in DCM
- Role of mitochondrial dysfunction and oxidative stress
- Impact of insulin resistance and altered glucose metabolism
- Novel biomarkers for early detection and risk stratification
- Advances in imaging modalities for the diagnosis of DCM
- Therapeutic interventions: pharmacological, lifestyle, and device-based approaches
- Sex differences and genetic predisposition in DCM progression
- Animal models and translational research in DCM
- Integration of artificial intelligence in the diagnosis and management of DCM
- Hyperglycemic memory in diabetic cardiomyopathy
- Pathophysiology, mechanisms, and treatments
- Diagnostic approaches for diabetic cardiomyopathy
- RNA-based mechanisms (non-coding RNAs - lncRNA, miRNA, CircRNAs; epitranscriptomics)
- Genetics, Epigenetics/Epigenomics regulation
- Preclinical models of diabetic cardiomyopathy; Modelling Using Induced Pluripotent Stem Cells
- The gut microbiota and diabetic cardiomyopathy
- Current therapeutic approaches, Challenges facing current therapies
- New therapies based on gene delivery, cell replacement, and SGLT-2 inhibitors
- Alternative therapies: Novel bioactive compounds and peptides
Prof. Djamel Lebeche
Guest Editor
Keywords
- diabetes mellitus
- diabetic cardiomyopathy
- heart failure
- cardiac fibrosis
- cardiomyocyte hypertrophy
- diastolic dysfunction
- hyperglycemia
- hyperlipidemia
- hyperinsulinemia
- metabolism
- molecular imaging
- energetics
- non-coding RNAs
- mitochondrial dysfunction
- immune response
- therapy
- DCM models (animals, organoids, organ-on-a-chip)
Manuscript Submission Information
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