IMR Press / RCM / Volume 25 / Issue 2 / DOI: 10.31083/j.rcm2502066
Open Access Review
Left Main Coronary Artery Disease: A Contemporary Review of Diagnosis and Management
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1 Department of Cardiology, Emory University, Atlanta, GA 30322, USA
2 Department of Internal Medicine, Emory University, Atlanta, GA 30322, USA
3 Department of Family Medicine, West Chicago Immediate Care, West Chicago, IL 60185-2847, USA
4 Department of Internal Medicine, Dow Medical College, 75300 Karachi, Pakistan
5 Department of Internal Medicine, Capital Health Regional Medical Centre, Trenton, NJ 08638-4143, USA
6 Department of Internal Medicine, The University of Mississippi Medical Center, Jackson, MS 39216, USA
7 Harrington Heart & Vascular Institute, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, OH 44106-2333, USA
8 Department of Cardiology, The Texas Heart Institute, Baylor College of Medicine, Houston, TX 77030, USA
9 Cardiology Division, NYU Langone Health and NYU School of Medicine, New York, NY 10016, USA
*Correspondence: (Chayakrit Krittanawong)
Rev. Cardiovasc. Med. 2024, 25(2), 66;
Submitted: 2 November 2023 | Revised: 10 December 2023 | Accepted: 29 December 2023 | Published: 18 February 2024
(This article belongs to the Special Issue The Treatment of Complex Coronary Artery Disease)
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Significant left main coronary artery disease is a very high-risk subgroup of coronary artery disease that is a crucial indicator of heightened morbidity and mortality rates. Despite its clinical significance, uncertainties persist regarding the optimal management strategy for patients, particularly given its phenotypic variations. Existing evidence-based guidelines offer insights into revascularization options, yet questions remain regarding long-term prognoses and clinical outcomes when comparing percutaneous coronary intervention to coronary artery bypass grafting. This comprehensive review aims to provide an in-depth analysis of contemporary strategies for the diagnosis, assessment, and treatment of left main coronary artery disease. By synthesizing current literature and addressing the evolving landscape of revascularization modalities, this review seeks to contribute valuable insights for clinicians and researchers grappling with the complexities of managing left main coronary artery disease.

left main coronary artery disease
percutaneous coronary intervention
coronary artery bypass grafting
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