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- Academic Editor
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†These authors contributed equally.
Background: To investigate the relationship between red blood cell
(RBC) folate and congestive heart failure (CHF). Methods: We extracted
the concentrations of RBC folate and collated CHF information from the National
Health and Nutrition Examination Survey (NHANES) survey (12820 individuals).
Weighted univariate logistic regression, weighted multivariate logistic
regression, and restrictive cubic spline (RCS) were used to assess the
relationship between RBC folate concentrations and CHF. Results: The
unadjusted model showed that the highest tertile group of RBC folate
concentration was significantly associated with a higher risk of CHF compared to
the lowest tertile group of RBC folate levels (odds ratio [OR] = 3.09; 95%
confidence interval [CI], 2.14–4.46). Similar trends were seen in the
multivariate-adjusted analysis (OR = 1.98; 95% CI: 1.27–3.09). The OR was