*Correspondence: tangyida@bjmu.edu.cn (Yi-Da Tang)
†These authors contributed equally.
Background: The high prevalence of chronic obstructive pulmonary
disease (COPD) in coronary artery disease (CAD) has been acknowledged over the
past decade, although the cause/s remain uncertain due to differences in
diagnoses. COPD has also become a leading CAD comorbidity, although again little
is known about its interactions. This meta-analysis explored COPD prevalence in
the global CAD population, as well as the influence of COPD on CAD.
Methods: PubMed, Web of Science, Embase, and grey literature were
searched until 26th November 2021. The prevalence of COPD was calculated, and
data were grouped according to COPD diagnostic methods, interventions, region,
economic status, etc. Outcomes including all-cause death, cardiac death,
myocardial infarction, revascularization, stroke, heart failure, and respiratory
failure were analyzed. This study was registered with PROSPERO (CRD
No.42021293270). Results: There was an average prevalence of 14.2% for
COPD in CAD patients (95% CI: 13.3–15.1), with diagnostics of COPD through
spirometry, International Classification of the Diseases (ICD codes), and self-reported methods. Comorbid COPD–CAD patients
were more likely to be smokers and suffer from cardiovascular and respiratory
complications (all odds ratios [OR]