- Academic Editor
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Acute pericarditis is the most frequent pericardial disease characterized by
inflammation of the pericardial layers resulting in pain, dyspnea and fatigue.
Often limited to an isolated event, up to 30% of patients experience one or more
recurrences. There is limited knowledge about the pathophysiology of this
disease, possibly due to the limited availability of animal models. More
recently, following seminal clinical trials with colchicine and interleukin-1
(IL-1) blockers and a novel murine model of acute pericarditis using zymosan A,
it has become clear that the NLRP3 (NACHT, leucine-rich repeat, and pyrin
domain-containing protein 3) inflammasome/IL-1