†These authors contributed equally.
Academic Editors: Simonetta Genovesi, Giuseppe Regolisti and Jerome L. Fleg
Background: Preexisting cardiovascular disease (CVD) and hypertension
are each associated with poor prognosis in peritoneal dialysis (PD) patients.
Joint associations of preexisting CVD and hypertension have not been
comprehensively evaluated in this population. Methods: We conducted a
retrospective cohort study of 3073 Chinese incident PD patients from five
dialysis centres between January 1, 2005, and December 31, 2018. The joint
associations between preexisting CVD, hypertension, and mortality were analysed
using Cox regression models. Results: Over a median of 33.7 months of
follow-up, 581 (18.6%) patients died, with 286 (9.3%) deaths due to CVD. After
adjusting for confounding factors, the preexisting CVD coexisting with
hypertension, preexisting CVD, and hypertension groups had higher risks of
all-cause mortality (hazard ratio [HR]: 3.97, 95% confidence interval [CI]: 3.06
to 5.15; HR: 2.21, 95% CI: 1.29 to 3.79; and HR: 1.83, 95% CI: 1.47 to 2.29,
respectively) and CVD mortality (HR: 4.68, 95% CI: 3.27 to 6.69; HR: 2.10, 95%
CI: 0.95 to 4.62; and HR: 1.86, 95% CI: 1.36 to 2.54, respectively) than the
control group without preexisting CVD or hypertension (p for trend