IMR Press / RCM / Volume 24 / Issue 1 / DOI: 10.31083/j.rcm2401022
Open Access Review
Cardiotoxicity as a Possible Side Effect of Statins
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1 Department of Histology and Embryology, Samara State Medical University, 443099 Samara, Samara Region, Russia
2 Department of Cardiology and Cardiovascular Surgery, Samara State Medical University, 443099 Samara, Samara Region, Russia
3 Research Institute of Cardiology, Samara State Medical University, 443099 Samara, Samara Region, Russia
*Correspondence: (Aleksey Chaulin)
Academic Editor: Vincent Figueredo
Rev. Cardiovasc. Med. 2023, 24(1), 22;
Submitted: 12 October 2022 | Revised: 17 November 2022 | Accepted: 21 November 2022 | Published: 11 January 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

According to current views, statins have a wide range of beneficial effects (lipid and non-lipid) on the cardiovascular system, so they are one of the most commonly used drugs for the prevention and management of patients with cardiovascular diseases. However, it is important to note that information about many beneficial effects of statins is contradictory. In addition, a number of side effects of statins, in particular, myotoxicity, hepatotoxicity, diabetogenic property, etc., may limit the possibility of using statins or even force doctors to cancel these drugs. Also, some concerns are caused by recent studies reporting cardiotoxicity of statins and increased serum concentrations of biomarkers of myocardial damage (highly sensitive cardiac troponins (hs-cTns)) in patients taking statins. This article discusses in detail the possible mechanisms of cardiotoxicity of statins and outlines the directions for further research in this area.

side effect
cardiac troponins
highly sensitive cardiac troponins
Fig. 1.
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