†These authors contributed equally.
Academic Editor: Jane A. Leopold
Background: Serum uric acid (SUA) levels has been
considered a possible risk factor for coronary artery disease (CAD) for many
years. Since SUA levels are greatly affected by medications, diet, and
metabolism, the association between SUA and CAD has been controversial for
centuries. While, the state of hyperuricemia (HUA) has been proven to have a
negative impact on CAD in previous studies, there are still few clinical and
epidemiological studies of HUA in CAD. In particular, evidence of this
association is limited in postmenopausal women. This study explored the influence
of SUA levels and HUA on CAD in this demographic group. Methods: In
total, 5435 postmenopausal women were allocated to either a non-CAD group (n =
2021) or a CAD group (n = 3414). Regression analyses, including generalized
linear models (GLM), correlation analysis, comparison between stratified groups,
and analysis by use of diuretics were carried out on data obtained in this study.
Results: SUA and HUA were found to associate significantly with CAD by
univariate logistic regression analysis. In addition, GLM showed nonlinear
response of CAD probability with increasing level of SUA. In multivariate
analysis, we found that SUA and HUA were independently related to CAD.
Correlation analysis showed that SUA and HUA both correlated positively with CAD
(p