IMR Press / RCM / Volume 23 / Issue 5 / DOI: 10.31083/j.rcm2305169
Open Access Short Communication
Focus on Cellular Iron Metabolism in Aortic Disease
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1 Department of Cardiovascular and Renal Medicine, Hyogo Medical University, 663-8501 Nishinomiya, Japan
*Correspondence: (Yoshiro Naito)
Academic Editor: Francesco Onorati
Rev. Cardiovasc. Med. 2022, 23(5), 169;
Submitted: 9 February 2022 | Revised: 16 March 2022 | Accepted: 22 March 2022 | Published: 11 May 2022
(This article belongs to the Special Issue Risk Factors for Cardiovascular Diseases)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Iron deficiency leads to health problems. Conversely, iron overload induces the generation of reactive oxygen species and health problems. Body iron status contributes to the development of various diseases, including aortic disease. Indeed, several clinical studies have reported that iron status can be linked to the pathogenesis of aortic disease. At the cellular level, iron uptake is regulated by the cellular iron transporter, transferrin receptor 1, while systemic iron homeostasis is regulated by hepcidin. As body iron status is regulated to maintain cellular and systemic iron homeostasis, iron metabolism in aortic disease is puzzling and not well understood. Methods: Perspective and short communication. Conclusions: This review provides an overview of the relevant research investigating the association between cellular iron metabolism and aortic disease.

abdominal aortic aneurysm
transferrin receptor 1
Fig. 1.
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