Exercise Training after Myocardial Infarction Attenuates Dysfunctional Ventricular Remodeling and Promotes Cardiac Recovery

¹ Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University, 226011 Nantong, Jiangsu, China

² Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, 200444 Shanghai, China

³ Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

^*Correspondence: junjiexiao@shu.edu.cn (Junjie Xiao); jingw@vt.edu (Jing Wang)
Academic Editors: Peter Kokkinos and Jonathan Myers

Rev. Cardiovasc. Med. 2022, 23(4), 148; https://doi.org/10.31083/j.rcm2304148

Submitted: 22 February 2022 | Revised: 26 March 2022 | Accepted: 7 April 2022 | Published: 19 April 2022

(This article belongs to the Special Issue Physical Activity and Fitness in the Prevention and Management of Cardiometabolic Disease)

This is an open access article under the CC BY 4.0 license.

Abstract

Recent evidences have shown that exercise training not only plays a necessary role in maintaining cardiac homeostasis, but also promotes cardiac repair after myocardial infarction. Post-myocardial infarction, exercise training has been observed to effectively increase the maximum cardiac output, and protect myocardial cells against necrosis and apoptosis, thus leading to an improved quality of life of myocardial infarction patients. In fact, exercise training has received more attention as an adjunct therapeutic strategy for both treatment and prevention of myocardial infarction. This review summarizes the experimental evidence of the effects of exercise training in ventricular remodeling after myocardial infarction, and tries to provide theoretical basis along with suitable references for the exercise prescription aimed at prevention and therapy of myocardial infarction.

Keywords

exercise training

ventricular remodeling

microRNA

myocardial Infarction

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Fig. 1.

Exercise training positively regulates calcium homeostasis, improves the balance between MMP-1 and TIMP-1, and enhances the expression of $\beta{}$ -adrenergic receptors. MMP-1, matrix metallopeptidase 1; TIMP-1, tissue inhibitor of metalloproteinases 1; SR, sarcoplasmic reticulum; $\beta{}$ -ARs, $\beta{}$ -adrenergic receptors.

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Rev. Cardiovasc. Med. Print ISSN 1530-6550 Electronic ISSN 2153-8174