IMR Press / RCM / Volume 23 / Issue 4 / DOI: 10.31083/j.rcm2304147
Open Access Review
Review of Laboratory Methods to Determine HDL and LDL Subclasses and Their Clinical Importance
Show Less
1 Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Science, Shaheed Beheshti University of Medical Sciences, 1985717413 Tehran, Iran
2 Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 1985717413 Tehran, Iran
*Correspondence: hedayati@endocrine.ac.ir; hedayati47@gmail.com (Mehdi Hedayati)
Academic Editor: Peter A. McCullough
Rev. Cardiovasc. Med. 2022, 23(4), 147; https://doi.org/10.31083/j.rcm2304147
Submitted: 5 October 2021 | Revised: 1 February 2022 | Accepted: 15 February 2022 | Published: 18 April 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Given the high prevalence of cardiovascular disease, accurate identification of methods for assessing lipoprotein subclasses, mainly low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subfractions, can play an essential role in predicting the incidence of cardiovascular disease such as heart attack. LDL and HDL subclasses differ in size, surface charge, lipid and protein compositions, and biological role. There is no “gold standard” method for measuring the LDL and HDL subclasses or standardizing the different methods used to measure their subfractions. Over the past decades, various techniques have been introduced to evaluate and measure subclasses of these two lipoproteins, each with its own advantages and disadvantages. Development of laboratory methods that accurately HDL and LDL function must be developed and validated to high-throughput for clinical usage. In this review study, we tried to examine different methods of evaluating various subclasses of LDL and HDL by mentioning the strengths and weaknesses of each.

Keywords
laboratory assessment
LDL
HDL
lipoprotein
review
Figures
Fig. 1.
Share
Back to top