IMR Press / RCM / Volume 23 / Issue 4 / DOI: 10.31083/j.rcm2304128
Open Access Systematic Review
Drug-coated Balloons in the Neurovascular Setting: A Comprehensive, Systematic Review of Current Use and Indications
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1 Neuroradiologische Klinik, Klinikum Stuttgart, 70174 Stuttgart, Germany
2 Neuroradiologisches Zentrum, Institut für Röntgendiagnostik, Universitätsklinikum Regensburg, 93053 Regensburg, Germany
3 Department of Neurosurgery, Neuroendovascular Center, Hadassah University Hospital, 91120 Jerusalem, Israel
4 Klinik für Radiologie, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany
5 Medizinische Fakultät, Universität Duisburg-Essen, 45147 Essen, Germany
*Correspondence: (Philipp von Gottberg)
Academic Editors: Massimo Volpe, Filippos Triposkiadis, Grigorios Korosoglou and Matteo Cameli
Rev. Cardiovasc. Med. 2022, 23(4), 128;
Submitted: 10 December 2021 | Revised: 13 January 2022 | Accepted: 21 January 2022 | Published: 2 April 2022
(This article belongs to the Special Issue State-of-the-Art Cardiovascular Medicine in Europe 2022)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Drug-coated balloons (DCB) are an established tool in the prevention and treatment of coronary and peripheral artery restenosis. The underlying effects of restenosis resemble those in the neurovascular field, yet data on the use of DCB in cervical and intracranial arteries is rare. Methods: Medline, and international and major national guidelines and recommendations were systematically searched for data addressing the use of DCB in the neurovascular setting. Results: Of the 1448 relevant records found in Medline, 166 publications were considered for this review. Conclusions: Data on the use of DCB in the neurovascular setting show a possible benefit over preceding alternatives, such as self-expanding stents, and balloon-mounted or drug-eluting stents. Nonetheless, the role of DCB remains under-researched, and publications remain lacking.

drug-coated balloons
percutaneous transluminal angioplasty
arterial stenosis
carotid artery stenosis
intracranial atherosclerotic stenosis
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