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Novel Approaches to Program Cells to Differentiate into Cardiomyocytes in Myocardial Regeneration
Victor Bonavida1, Kaitlyn Ghassemi1, Gwendolyn Ung1, Keiko Inouye1, Finosh G Thankam1, Devendra K Agrawal1,*
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1
Department of Translational Research, Western University of Health Sciences, Pomona, CA 91766, USA
*Correspondence: DAgrawal@westernu.edu (Devendra K Agrawal)
Academic Editors: Jerome Roncalli and Anthony Matta
Academic Editors: Jerome Roncalli and Anthony Matta
Rev. Cardiovasc. Med. 2022, 23(12), 392;
https://doi.org/10.31083/j.rcm2312392
Submitted: 15 September 2022 | Revised: 17 October 2022 | Accepted: 31 October 2022 | Published: 30 November 2022
(This article belongs to the Special Issue Tissue Repair and Regeneration in Heart Failure)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
With heart failure (HF) being one of the leading causes of hospitalization and death worldwide, multiple stem cell therapies have been attempted to accelerate the regeneration of the infarct zone. Versatile strategies have emerged to establish the cell candidates of cardiomyocyte lineage for regenerative cardiology. This article illustrates critical insights into the emerging technologies, current approaches, and translational promises on the programming of diverse cell types for cardiac regeneration.
Keywords
heart failure
cardiac regeneration
cell programming
iPSC
cell technologies
Funding
R01 HL144125/startup funds from WesternU. DK Agrawal
R01HL147662/startup funds from WesternU. DK Agrawal
Figures
Fig. 1.