IMR Press / RCM / Volume 23 / Issue 11 / DOI: 10.31083/j.rcm2311373
Open Access Review
Updates on Post-Resuscitation Care. After the Return of Spontaneous Circulation beyond the 2021 Guidelines
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1 Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
2 Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy
3 Department of Medical, Surgical, Diagnostic and Pediatric Science, University of Pavia, 27100 Pavia, Italy
4 Anesthesiology and Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
5 Department of Cardiology Copenhagen University Hospital, Hvidovre and Amager-Hospital, 2650 Copenhagen, Denmark
*Correspondence: (Simone Savastano)
Academic Editors: Massimo Volpe, Filippos Triposkiadis, Grigorios Korosoglou and Matteo Cameli
Rev. Cardiovasc. Med. 2022, 23(11), 373;
Submitted: 26 September 2022 | Revised: 11 October 2022 | Accepted: 11 October 2022 | Published: 31 October 2022
(This article belongs to the Special Issue State-of-the-Art Cardiovascular Medicine in Europe 2022)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Out-of-hospital cardiac arrest is one of the leading causes of mortality worldwide. The goal of resuscitation is often meant as the return of spontaneous circulation (ROSC). However, ROSC is only one of the steps towards survival. The post-ROSC phase is still a challenging one during which the risk of death is all but averted. Morbidity and mortality are exceedingly high due to cardiovascular and neurologic issues; for this reason, post ROSC care relies on international guidelines, the latest being published on April 2021. Since then, several studies have become available covering a variety of topics of crucial importance for post-resuscitation care such as the interpretation of the post-ROSC ECG, the timing of coronary angiography, the role of complete myocardial revascularization and targeted temperature management. This narrative review focuses on these new evidences, in order to further improve clinical practice, and on the need for a multidisciplinary and integrated system of care.

cardiac arrest
post-ROSC care
Fig. 1.
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