IMR Press / RCM / Volume 22 / Issue 3 / DOI: 10.31083/j.rcm2203110
Open Access Original Research
Predictive and prognostic value of v-set and transmembrane domain-containing 1 expression in monocytes for coronary artery disease
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1 Departments of Cardiology, Shanghai Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200011 Shanghai, China
2 Department of anesthesiology, Shanghai Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200011 Shanghai, China
These authors contributed equally.
Rev. Cardiovasc. Med. 2021, 22(3), 1009–1017; https://doi.org/10.31083/j.rcm2203110
Submitted: 20 June 2021 | Revised: 9 August 2021 | Accepted: 11 August 2021 | Published: 24 September 2021
(This article belongs to the Special Issue State-of-the-Art Cardiovascular Medicine in Asia 2021)
Abstract

The aim of this study was to investigate the correlation between v-set and transmembrane domain-containing 1 (VSTM1) expression and incidence of major adverse cardiac events (MACE) in patients with coronary heart disease (CHD). A total of 310 patients were divided into a non-acute coronary syndrome (non-ACS) group (containing the stable angina group, and the asymptomatic coronary artery diseaseand other patients group) and an ACS group (containing unstable angina and acute myocardial infarction patients). Monocytic VSTM1 expression levels (assessed via average fluorescence intensity derived from antibody binding to VSTM1) in each group were detected and analyzed. The cut-off value of monocytic VSTM1 expression to predict the onset of ACS and MACE was confirmed. VSTM1 expression in monocytes from the ACS group was lower than that of the non-ACS group. The incidence of MACEs in the high VSTM1-expression group was much less than that of those in the low VSTM1 expression group at the 1 year follow-up stage. VSTM1 expression had an independent-inversed association with increased incidence of MACE and ACS. VSTM1 expression in monocytes may help to predict the occurrence of ACS in patients with CHD, and moreover it may provide the means to evaluate MACE prognosis during CHD patient follow-up.

Keywords
Coronary artery disease
VSTM1
Predictive and prognostic value
Acute coronary syndrome
Stable coronary artery disease
Atherosclerosis
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