This study described the trend and distribution of coronary heart disease (CHD) in the Hexi Corridor region of Gansu. The CHD mortality rates from 2006–2015 were obtained through the Death Reporting System of Gansu Centers for Disease Control (CDC) for 2006–2015. The overall mortality rate of CHD in the Hexi Corridor showed a decreasing trend, increasing in winter and spring and lowest in summer. The CHD mortality rate was higher in men than in women (P 0.05) and increased with age (P 0.05). The mortality rate was higher in rural areas than in urban areas (P 0.05). A ten-year mortality rate trend analysis showed that CHD mortality rate in women has significantly decreased. Specifically, women aged 18–39 years experienced increased There was little change in CHD mortality among women aged 40–59 years, and a declined in CHD mortality among women 60 years and older and women in urban areas. Further analysis showed that in the 18–39-year-old and 40–59-year-old groups and in urban areas, CHD mortality rate was higher in men than in women (P 0.05). From 2006 to 2015, the mortality rate of CHD in the Hexi Corridor of Gansu was lower than in the national average, but in certain populations such as men, young and middle-aged group and rural areas, the CHD mortality rate was gradually increased. There has been a gradual and progressive decline in CHD mortality rate compared to the rising trend in China. This is due to fewer risk factors in the region, effective drug treatment and improvements in environmental pollution. However, there is still a need to enhance the experience of effective prevention and control for specific subgroups such as men, young people and rural residents, and to take appropriate measures to prevent the occurrence of CHD.