IMR Press / RCM / Volume 22 / Issue 3 / DOI: 10.31083/j.rcm2203098
Open Access Original Research
Clinical characteristics and outcomes in acute myocardial infarction patients aged 65 years in Western Romania
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1 Cardiology Clinic, Timisoara Municipal Clinical Emergency Hospital, 300024 Timișoara, Romania
2 Multidisciplinary Heart Research Center, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania

These authors contributed equally.

Rev. Cardiovasc. Med. 2021, 22(3), 911–918;
Submitted: 21 February 2021 | Revised: 10 May 2021 | Accepted: 21 June 2021 | Published: 24 September 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Older age is known as a negative prognostic parameter in patients with acute myocardial infarction (AMI). In this study, we aimed to investigate age-related differences in treatment protocols, in-hospital and 1-year mortality. This retrospective observational single-center study enrolled consecutive AMI patients with an urgent percutaneous coronary intervention (PCI) as the main method of myocardial revascularization. The patients divided were divided by age into group I (65 years) and group II (<65 years). The primary endpoint was in-hospital mortality, the secondary endpoints were 1-year mortality and rehospitalization rates. Of the 522 admitted with AMI, 476 were enrolled in the study. The mean age was 67 ± 13 years; 62% were men. Group I patients had a significantly lower rate of performed PCI (65% vs. 79%, P < 0.001). 53 patients (12.3%) died during hospitalization, and this proportion was notably higher in the older population (20% vs. 6%, P < 0.0001). The cardiac causes of death were more frequent in group I patients (12% vs. 5.6%, P = 0.016). The multivariate logistic regression selected two variables as independent predictors for the risk of in-hospital death: age 65 years (P = 0.0170), and Killip class at admission (P < 0.0001). The 1-year mortality was 3.3%, slightly higher in group I patients (4.8% vs. 1.5%, P = 0.05). In conclusion, patients aged 65 years have three times higher in-hospital mortality, but similar 1-year mortality and readmission rates when compared with the younger patients. It is obvious that there is a large potential for improvement of the AMI care in this age group of patients.

Acute myocardial infarction
Age ≥65 years
Fig. 1.
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