IMR Press / RCM / Volume 22 / Issue 3 / DOI: 10.31083/j.rcm2203080
Open Access Review
Current management and prognosis of patients with recurrent myocardial infarction
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1 Department of Cardiosciences, Division of Cardiology, A. O. San Camillo-Forlanini, 00152 Rome, Italy
2 Department of Medicine, Unit of Cardiovascular Science, Campus Bio-Medico University, 00128 Rome, Italy
3 Division of Cardiology, San Filippo Neri Hospital, 00186 Rome, Italy
4 Department of Cardiosciences, Cardiac Surgery Unit and Heart Transplantation Center, A. O. San Camillo-Forlanini, 00152 Rome, Italy
Academic Editor: Peter A. McCullough
Rev. Cardiovasc. Med. 2021, 22(3), 731–740;
Submitted: 30 May 2021 | Revised: 29 July 2021 | Accepted: 4 August 2021 | Published: 24 September 2021

Recurrent myocardial infarction (re-MI) is a common event following acute coronary syndrome (ACS), especially during the first year. According to epidemiological studies, patients who experience re-MI are at higher risk of all-cause cardiovascular events and mortality. The cornerstones of re-MI prevention include complete functional coronary revascularization, effective dual antiplatelet therapy and secondary prevention strategies. Notwithstanding this, some controversy still exists on the definition and management of re-MI, and no dedicated studies have been designed or conducted so far in this setting. We here provide an overview of epidemiological and prognostic data on ACS patients experiencing re-MI, along with current available treatment and preventive options.

Recurrent myocardial infarction
Acute coronary syndrome
Secondary prevention
Dual antiplatelet therapy
Percutaneous coronary intervention
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