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Open Access
Review
The Antiarrhythmic Effects of Ranolazine
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1
Department of Cardiovascular Medicine, William Beaumont Hospital–Oakland University School of Medicine, Rochester, MI
Rev. Cardiovasc. Med. 2009, 10(S1), 38–45;
https://doi.org/10.3909/ricm10S10006
Published: 20 January 2009
Abstract
The genesis of cardiac arrhythmia can be grouped into 3 common mechanisms:
abnormal automaticity, triggered activity, and re-entry. Alteration of automaticity,
triggered activity, conduction, and/or refractoriness of myocardial tissue by drugs
will perturb and often prevent the occurrence of arrhythmias. Ranolazine is a
novel agent approved in the United States for antianginal therapy. The potential
of ranolazine as an antiarrhythmic drug stems from observation of its ability
to modify multiple ionic currents in cardiac cells responsible for generation of
the action potential. In contrast to currently available antiarrhythmic drugs,
ranolazine is well tolerated and has few side effects. Small clinical trials suggest
that ranolazine may have a role in the treatment of patients with non–STelevation
acute coronary syndrome, atrial fibrillation, long QT syndromes,
and sinus node dysfunction.
Keywords
Arrhythmia
Myocardial tissue
Non–ST-elevation acute coronary syndrome
Antianginal therapy
Ranolazine