Die Pharmazie is published by IMR Press from Volume 81 Issue 1 (2026). Previous articles were published by another publisher under the CC-BY licence, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement.
Inhibition of carbonic anhydrase II by sulfonamide derivatives
G. S. Xuan 1, J. H. Zhan 1, A. M. Zhang 1, W. Li 1, K. Zheng 2
Affiliations
Article Info
1 College of Chemical Engineering, Qingdao University of Science & Technology, Qingdao, PR China
2 College of Chemical Engineering, Qingdao University of Science & Technology, Qingdao, PR China;, Email: zhengke@qust.edu.cn
Abstract
A series of sulfonamide derivatives were synthesized, and the enzyme inhibitory activity of the synthesized compounds on carbonic anhydrase II was evaluated. Through molecular docking studies, it was found that compounds 1b, 1e, 2a, 2b, 3a have a strong binding affinity to carbonic anhydrase II. The IC50 values of the four compounds 1e, 2b, 3a, and 3b were lower than that of the positive control drug acetazolamide. What's more, the compounds had a high inhibitory activity for A549 lung cancer cell growth, among them, 1e and 3a could inhibit both carbonic anhydrase II and lung cancer cell proliferation.