New Perspectives on the Mechanisms of Epileptogenesis and the Pursuit of Targeted Therapies
Submission Deadline: 31 Oct 2025
Guest Editors
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, China;Key Laboratory of Major Brain Disease and Aging Research（Ministry of Education), Chongqing Medical University, Chongqing, China
Interests: epilepsy; epileptogenesis; pharmacoresistant epilepsy; synaptic plasticity; anti-seizure drugs
Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China
Interests: neuropharmacology; molecular and neural circuitry mechanisms of epilepsy; electrophysiology
Songjiang Hospital and Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Interests: glial cells; neuroinflammation; temporal lobe epilepsy
Special Issue Information
Dear Colleagues,
Epilepsy ranks among the most prevalent neurological disorders, characterized by unprovoked recurrent seizures and significant disease burden. Currently available anti-seizure drugs (ASDs), which primarily target membrane ion channels or neural transmission pathways, are the first-line treatment for seizure control. However, existing ASDs have proven ineffective in intervening in the process of epileptogenesis.
In recent years, substantial advancements in neuroscientific techniques—such as optogenetics, neural circuitry tracing, and high-throughput sequencing—have facilitated a deeper understanding of the neural circuitry and molecular mechanisms underlying epileptogenesis. Further investigations based on these developments are crucial for discovering and developing promising new therapeutic approaches.
This Research Topic aims to explore novel mechanisms of epileptogenesis and potential therapeutic strategies inspired by emerging targets. We invite submissions of Original Research articles and Reviews that address, but are not limited to, the following themes:
- Investigations into cellular and molecular mechanisms of epileptogenesis with potential translational significance.
- Exploration of innovative therapeutic approaches aimed at intervening in the process of epileptogenesis.
Prof. Xin Tian, Cenglin Xu and Zhangpeng Chen
Guest Editors
Keywords
- epilepsy
- epileptogenesis
- therapeutic approaches