IMR Press / JIN / Volume 22 / Issue 1 / DOI: 10.31083/j.jin2201019
Open Access Review
The Role of Ferroptosis in Nervous System Disorders
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1 Department of Anaesthesiology and Perioperative Medicine and Department of Intensive Care Unit, Xijing Hospital, The Fourth Military Medical University, 710032 Xi’an, Shaanxi, China
2 College of Life Sciences, Northwest University, 710069 Xi’an, Shaanxi, China
*Correspondence: (Zongping Fang); (Xijing Zhang)
These authors contributed equally.
Academic Editor: Drozdstoy Stoyanov
J. Integr. Neurosci. 2023, 22(1), 19;
Submitted: 24 June 2022 | Revised: 29 July 2022 | Accepted: 1 August 2022 | Published: 16 January 2023
(This article belongs to the Special Issue Advances in Depression Research)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Ferroptosis is distinct from other apoptotic forms of programmed cell death and is characterized by the accumulation of iron and lipid peroxidation. Iron plays a crucial role in the oxidation of lipids via the Fenton reaction with oxygen. Hence, iron accumulation causes phospholipid peroxidation which induces ferroptosis. Moreover, detoxification by glutathione is disrupted during ferroptosis. A growing number of studies have implicated ferroptosis in nervous system disorders such as depression, neurodegenerative disease, stroke, traumatic brain injury, and sepsis-associated encephalopathy. This review summarizes the pathogenesis of ferroptosis and its relationship with various nervous system disorders.

lipid peroxidation
nervous system disorders
81871603/National Nature Science Foundation Grant
XJZT21J08/Discipline Boost Program of the First Affiliated Hospital of Air Force Military Medical University
Fig. 1.
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