IMR Press / JIN / Volume 21 / Issue 6 / DOI: 10.31083/j.jin2106168
Open Access Original Research
Sleep Duration Positively Correlates with Global Cognition in the Non-Demented Older Adults with High School or above Education
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1 Department of Neurology, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science & Collaborative Innovation Center for Brain Science, Zhongshan Hospital, Fudan University, 200032 Shanghai, China
2 Department of Neurology, Zhongshan Hospital, Fudan University (Xiamen Branch), 361015 Xiamen, Fujian, China
*Correspondence:; (Chunjiu Zhong);; (Guoqiang Fei)
These authors contributed equally.
Academic Editor: Luigi De Gennaro
J. Integr. Neurosci. 2022, 21(6), 168;
Submitted: 8 June 2022 | Revised: 23 July 2022 | Accepted: 26 July 2022 | Published: 24 October 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Sleep disturbance is common in the elderly. The effect of sleep duration on cognitive function in the non-demented older adults with high school or above education needs to be clarified. Here, we conducted a cross-sectional study to explore the correlation between sleep duration and multi-domain cognitive function in non-demented older adults. Methods: A total of 226 adults aged 60 years and over who have an educational background over 9 years, received a battery of neuropsychological evaluations. The Mini-Mental State Examination (MMSE) was used to assess global cognitive function, the Auditory Verbal Learning Test (AVLT), Verbal Fluent Test (VFT), Trial Making Test-A/B (TMT-A/B), Symbol Digit Modalities Test (SDMT), and Rey-Osterriech Complex Figure Test (CFT) were used to assess the memory, language, attention and executive, and visuospatial functions respectively. Sleep characteristics were collected by questionnaire. Results: Subjects with sleep disturbance performed worse in visuospatial ability as compared with those with normal sleep. A significant correlation between nocturnal/total sleep duration and MMSE scores and CFT scores was found in overall subjects using linear regression models after adjusting for age, gender, education and BMI. Consistently, the nocturnal/total sleep duration positively correlated with MMSE scores after controlling for age, gender, education, BMI, hypertension, diabetes, hyperlipidemia, coronary artery disease and household conditions. Conclusions: The results indicate that shorter sleep duration impairs the global cognition and visuospatial ability in the older adults with high school or above education, even in the very early non-demented stage.

sleep duration
cognitive function
visuospatial ability
older adults
91332201/National Natural Science Foundation of China
82171411/National Natural Science Foundation of China
2020CXB049/Medical Innovation Program of Fujian Health Committee
3502Z20194028/Medical and Health Technology Program of Science and Technology Bureau in Xiamen
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