IMR Press / JIN / Volume 21 / Issue 6 / DOI: 10.31083/j.jin2106154
Open Access Original Research
The Relationship Between Serum Netrin-1 Expression Levels and Prognosis in Revascularized Patients with Acute Ischemic Stroke
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1 Department of Neurology Medical, Jinshan branch of Shanghai Sixth People's Hospital, 201599 Shanghai, China
2 Department of Renal Medical, Jinshan branch of Shanghai Sixth People's Hospital, 201599 Shanghai, China
*Correspondence: zliuzhenqe@163.com (Zhen Liu)
Academic Editor: Emilia Salvadori
J. Integr. Neurosci. 2022, 21(6), 154; https://doi.org/10.31083/j.jin2106154
Submitted: 18 February 2022 | Revised: 12 April 2022 | Accepted: 12 April 2022 | Published: 20 September 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: This study aimed to explore the relationship between serum netrin-1 expression levels and acute prognosis in patients with acute ischemic stroke (AIS) within 24 hours after revascularization. Methods: A total of 121 revascularized patients admitted to the Jinshan Branch of the Shanghai Sixth People’s Hospital, China, between July 2019 and July 2021 were selected as study subjects. The primary outcome was the modified Rankin Scale (mRS) score three months after revascularization: patients with an mRS score >2 were classified into the unfavorable prognosis group and others into the favorable prognosis group. Those with serum netrin-1 expression levels greater than the median of all patients were classified into the elevated protein group and others into the decreased protein group. Multivariate logistic regression analysis was used to analyze the independent risk factors for prognosis in patients with AIS after revascularization. Results: The differences between the unfavorable prognosis group and the favorable prognosis group in gender, age, coronary heart disease, and netrin-1 levels were not statistically significant (p > 0.05). However, the National Institute of Health Stroke Scale (NIHSS) scores and number of patients with comorbid hypertension in the unfavorable prognosis group were significantly higher than in the favorable prognosis group (p < 0.05). Multivariate logistic regression analysis showed that NIHSS score before revascularization was an independent risk factor for unfavorable prognosis but that netrin-1 expression levels were not significantly associated with prognosis in patients after revascularization. Conclusions: Serum netrin-1 expression levels in the acute phase are not significantly associated with prognosis in patients with AIS after revascularization.

Keywords
revascularization
netrin-1
prognosis
risk factors
Funding
2019-3-12/ Scientific Research Foundation of Jinshan District Science and Technology Committee
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