Background: This study aimed to explore the relationship between serum
netrin-1 expression levels and acute prognosis in patients with acute ischemic
stroke (AIS) within 24 hours after revascularization. Methods: A total
of 121 revascularized patients admitted to the Jinshan Branch of the Shanghai
Sixth People’s Hospital, China, between July 2019 and July 2021 were selected as
study subjects. The primary outcome was the modified Rankin Scale (mRS) score
three months after revascularization: patients with an mRS score 2 were
classified into the unfavorable prognosis group and others into the favorable
prognosis group. Those with serum netrin-1 expression levels greater than the
median of all patients were classified into the elevated protein group and others
into the decreased protein group. Multivariate logistic regression analysis was
used to analyze the independent risk factors for prognosis in patients with AIS
after revascularization. Results: The differences between the
unfavorable prognosis group and the favorable prognosis group in gender, age,
coronary heart disease, and netrin-1 levels were not statistically significant
(p 0.05). However, the National Institute of Health Stroke Scale
(NIHSS) scores and number of patients with comorbid hypertension in the
unfavorable prognosis group were significantly higher than in the favorable
prognosis group (p 0.05). Multivariate logistic regression analysis
showed that NIHSS score before revascularization was an independent risk factor
for unfavorable prognosis but that netrin-1 expression levels were not
significantly associated with prognosis in patients after revascularization.
Conclusions: Serum netrin-1 expression levels in the acute phase are not
significantly associated with prognosis in patients with AIS after
revascularization.
