IMR Press / JIN / Volume 21 / Issue 6 / DOI: 10.31083/j.jin2106149
Open Access Original Research
White Matter Integrity of the Corticospinal Tract for Estimation of Individual Patient Risk for Postoperative Neurological Deterioration after Glioma Surgery
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1 Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, Germany
2 Institute of Neuroradiology, University Hospital Leipzig, 04103 Leipzig, Germany
3 Department of Radiology, University Hospital Leipzig, 04103 Leipzig, Germany
*Correspondence: tim.wende@medizin.uni-leipzig.de (Tim Wende)
These authors contributed equally.
Academic Editors: Imran Khan Niazi and Gernot Riedel
J. Integr. Neurosci. 2022, 21(6), 149; https://doi.org/10.31083/j.jin2106149
Submitted: 23 June 2022 | Revised: 21 July 2022 | Accepted: 29 July 2022 | Published: 19 September 2022
(This article belongs to the Special Issue Advances in Neurorehabilitation)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: Tractography has become a standard tool for planning neurosurgical operations and has been proven to be useful for risk stratification. In various conditions, tractography-derived white matter integrity has been shown to be associated with neurological outcome. Postoperative performance has been shown to be a prognostic marker in glioma. We aimed to assess the relation of preoperative corticospinal tract (CST) integrity with postoperative neurological deterioration in patients with malignant glioma. Methods: We retrospectively analyzed a cohort of 24 right-handed patients (41.7% female) for perioperative neurological performance score (NPS) and applied our anatomical tractography workflow to extract the median fractional anisotropy (FA) of the CST in preoperative magnetic resonance imaging (MRI). Results: Median FA of the CST ipsilateral to the tumor correlated significantly with preoperative NPS (p = 0.025). After rank order correlation and multivariate linear regression, we found that the preoperative median FA of the right CST correlates with preoperative NPS, independently from epidemiological data (p = 0.019). In patients with lesions of the right hemisphere, median FA of the right CST was associated with a declining NPS in multivariate linear regression (p = 0.024). Receiver operating characteristic (ROC) analysis revealed an optimal FA cutoff at 0.3946 in this subgroup (area under the curve 0.83). Patients below that cutoff suffered from a decline in neurological performance significantly more often (p = 0.020). Conclusions: Assessment of preoperative white matter integrity may be a promising biomarker for risk estimation of patients undergoing craniotomy for resection of malignant glioma.

Keywords
corticospinal tract
DTI
glioma
MRI
neurological performance
tractography
Figures
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