IMR Press / JIN / Volume 21 / Issue 5 / DOI: 10.31083/j.jin2105135
Open Access Original Research
Sleep Deprivation Increases the Anesthetic Potency of Sevoflurane Regardless of Duration
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1 Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430000 Wuhan, Hubei, China
*Correspondence: (Shihai Zhang)
Academic Editor: Luigi De Gennaro
J. Integr. Neurosci. 2022, 21(5), 135;
Submitted: 12 January 2022 | Revised: 17 March 2022 | Accepted: 30 March 2022 | Published: 22 July 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Sleep deprivation reduced the time to induce anesthesia by propofol and isoflurane and prolonged the time to recovery. However, it is unknown whether sleep deprivation affects the potency of inhaled anesthetics. In this study, the effect of sleep deprivation on sevoflurane anesthetic potency was explored. Methods: Ten animals received the following behavioral interventions in turn (ad libitum activity, 24 h sleep deprivation, 48 h sleep deprivation, 72 h sleep deprivation). After each behavioral intervention, the 50% effective dose for loss of righting reflex (LORR ED50) was determined to evaluate the potency of sevoflurane in inducing unconsciousness in mice. Repeated-measures analysis of variance was used to compare our behavioral interventions statistically, post hoc multiple comparisons were made using the Bonferroni test. Results: Sleep deprivation decreased the sevoflurane LORR ED50 significantly (p = 0.0003). However, the effect of duration of sleep deprivation on LORR ED50 was not statistically significant (p > 0.9999). Conclusions: Sleep deprivation can increase the anesthetic potency of sevoflurane regardless of duration of sleep deprivation.

sleep deprivation
anesthetic potency
Fig. 1.
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