IMR Press / JIN / Volume 21 / Issue 2 / DOI: 10.31083/j.jin2102059
Open Access Original Research
Impact of a 12-month multifaceted neurological physiotherapy intervention on gross motor function in women with Rett syndrome
Show Less
1 Alma Mater Europaea – ECM Maribor, 2000 Maribor, Slovenia
2 Modus Medical, 2000 Maribor, Slovenia
3 Medical Rehabilitation Unit, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia
4 Department of Neurosurgery, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia
*Correspondence: (Alen Kapel)
Academic Editor: Rafael Franco
J. Integr. Neurosci. 2022, 21(2), 59;
Submitted: 1 November 2021 | Revised: 14 January 2022 | Accepted: 14 January 2022 | Published: 22 March 2022
(This article belongs to the Special Issue Neuropediatrics, from basic science to clinical practice)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Rett syndrome is a rare genetic neurological syndrome that affects mostly females. The syndrome leads to severe impairments impacting all areas of the affected persons’ life, including speech, mobility, eating, and breathing impairments. The most distinct symptoms include stereotyped hand movements, ataxia, and atrophy of the lower limbs, and signs of autism. Methods: According to the principle of convenience sampling, the quantitative research included five females diagnosed with Rett syndrome subject to their personalized goal oriented neurological physiotherapy. Changes in gross motor function were assessed by the Gross Motor Function Measure 88 and Rett syndrome Gross Motor Scale. Results: It was found that the 12-month multifaceted neurological physiotherapy intervention had statistically significant improvements in both Gross Motor Function Measure 88 (p = 0.005) and Rett syndrome Gross Motor Scale (p = 0.012). Despite positive improvements, the absence of control group made it difficult for a comparative evaluation to determine what interventions had the best possible outcomes. Conclusions: The quantitative research demonstrates neuro-developmental treatment sessions, hippotherapy, hydrotherapy, physical therapy, a walking program, endurance exercises, active-assisted exercises, and coordination exercises, had a significant impact on improving gross motor function status. Current multifaceted intervention program leads to good improvement of gross motor skills above what can be expected from late motor deterioration.

Rett syndrome
Gross motor function
Neurological physiotherapy
Genetic neurological disorder
Back to top