IMR Press / JIN / Volume 17 / Issue 2 / DOI: 10.31083/JIN-170051
Open Access Meta-analysis
Association between SORL1 polymorphisms and the risk of Alzheimer's disease
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1 Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin Province, China
2 Institute of Clinical Medicine, Jilin University, Changchun, 130021, China
3 Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin Province, China
*Correspondence: zhaoqing@jlu.edu.cn (Qing Zhao)
J. Integr. Neurosci. 2018, 17(2), 185–192; https://doi.org/10.31083/JIN-170051
Submitted: 18 July 2017 | Accepted: 22 September 2017 | Published: 15 May 2018
Abstract

A meta-analysis was performed to identify empirical data assessing the effects of a single nucleotide polymorphisms of sortilin-related receptor on Alzheimer's disease based on 14 studies involving 37941 cases and 49727 control studies. Analysis showed, (i) Increased risk between the single nucleotide polymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility in Asian populations, (ii) Single nucleotide polymorphism rs689021 was associated with decreased risk in Caucasians, and (iii) Single nucleotide polymorphism rs641120 was detected as a decreased risk in both populations. Given these data, crucial evidence is provided to demonstrate that a significant relationship exists between SORL1 polymorphisms and susceptibility to Alzheimer's disease.

Keywords
Alzheimer's disease
single nucleotide polymorphisms
sortilin-related receptor
neurogenomics
susceptibility
sortilin related receptor 1
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