Volume 18, Issue 4 (2022)

International Journal of Pharmacology (IJP) is published by IMR Press from Volume 21 Issue 4 (2025). Previous articles were published by another publisher under the CC-BY licence, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement.

Volume 18, Issue 4 (2022)

Diagnosis and Treatment of Non-Small Cell Lung Cancer: Adenosine Triphosphate Tumor Chemosensitivity Assay

Open Access Research Article

Diagnosis and Treatment of Non-Small Cell Lung Cancer: Adenosine Triphosphate Tumor Chemosensitivity Assay

Jing Song, Jing Peng, Xiaoyun Liu, Dexi Zhou, Chunyan Yang, Jiajie Luan

Int. J. Pharmacol. 2022, 18(4), 842-849; https://doi.org/10.3923/ijp.2022.842.849

Abstract

Download

Levonorgestrel and Desogestrel Modulate Gut Microbiota and Blood Biochemistry of Female Wistar Rats

Open Access Research Article

Levonorgestrel and Desogestrel Modulate Gut Microbiota and Blood Biochemistry of Female Wistar Rats

Moaz A. Al-Ghamdi, Othman A. Baothman, Muhammad Afzal, Sami I. Alzarea, Firoz Anwar, Muhammad Shahid Nadeem, Imran Kazmi

Int. J. Pharmacol. 2022, 18(4), 826-841; https://doi.org/10.3923/ijp.2022.826.841

Abstract

Download

Evaluating the Effects of Hypotensive Drug Valsartan on Angiogenesis and Associated Breast Ductal Carcinoma Cell Metastasis

Open Access Research Article

Evaluating the Effects of Hypotensive Drug Valsartan on Angiogenesis and Associated Breast Ductal Carcinoma Cell Metastasis

Ashok Munjal, Rekha Khandia, Saumi Paladhi, Megha Pandey, Arpana Parihar, Chandrashekhar Pathe, K. Rajukumar, Talha Bin Emran, Taha Alqahtani, Ali M. Alqahtani, Ali H. Alamri, Kumarappan Chidambaram, Kuldeep Dhama

Int. J. Pharmacol. 2022, 18(4), 817-825; https://doi.org/10.3923/ijp.2022.817.825

Abstract

Download

Curcumin Improving Drug Resistance of MDA-MB-231/DDP Tumor Treatment by Enhancing Autophagy

Open Access Research Article

Curcumin Improving Drug Resistance of MDA-MB-231/DDP Tumor Treatment by Enhancing Autophagy

Ming-Qin Qian, Xian-De Ma, Guo-Wei Pan

Int. J. Pharmacol. 2022, 18(4), 806-816; https://doi.org/10.3923/ijp.2022.806.816

Abstract

Download

102

Effects of Omega-3 Fatty Acid-Rich Zanthoxylum schinifolium Seed Oil in Patients with Dry Eye: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial

Open Access Research Article

Effects of Omega-3 Fatty Acid-Rich Zanthoxylum schinifolium Seed Oil in Patients with Dry Eye: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial

In-Chon You, Su-Jin Jung, Eun-Ock Park, Byung-Hyun Park, Mun-Yhung Jung, Byung-Ok So, Jin-Woo Park, Soo-Wan Chae, Nam-Chun Cho

Int. J. Pharmacol. 2022, 18(4), 794-805; https://doi.org/10.3923/ijp.2022.794.805

Abstract

Download

114

Asiatic acid Improves Physical Fatigue through Regulating Inflammatory Reaction, Oxidative Stress and Energy Metabolism in Mice

Open Access Research Article

Asiatic acid Improves Physical Fatigue through Regulating Inflammatory Reaction, Oxidative Stress and Energy Metabolism in Mice

Xianchu Liu, Changhao Cheng, Ming Liu

Int. J. Pharmacol. 2022, 18(4), 783-793; https://doi.org/10.3923/ijp.2022.783.793

Abstract

Download

Involvement of High Expression of Interferon-Inducible M×1 in Systemic Lupus Erythematosus

Open Access Research Article

Involvement of High Expression of Interferon-Inducible M×1 in Systemic Lupus Erythematosus

Shibao Ye, Yu Zhuang, Zhifen Lv, Yuhang Chen

Int. J. Pharmacol. 2022, 18(4), 775-782; https://doi.org/10.3923/ijp.2022.775.782

Abstract

Effects of Gastrodia elata Blume on Cognitive Function Improvement: A 12 Weeks, Randomized, Double-Blind, Placebo-Controlled Pilot Study

Open Access Research Article

Effects of Gastrodia elata Blume on Cognitive Function Improvement: A 12 Weeks, Randomized, Double-Blind, Placebo-Controlled Pilot Study

Su-Jin Jung, Eun-Soo Jung, Yin Cui, Thong Ba Nguyen, Ki-Chan Ha, Hayang-Im Baek, Soog-Kyoung Han, Seung-Ok Lee, Soo-Wan Chae, Young-Chul Chung

Int. J. Pharmacol. 2022, 18(4), 765-774; https://doi.org/10.3923/ijp.2022.765.774

Abstract

Download

128

Oxidative Damage and Anti-Inflammatory Activity of Myricetin from Berries in Streptozotocin-Induced Diabetic Rats

Open Access Research Article

Oxidative Damage and Anti-Inflammatory Activity of Myricetin from Berries in Streptozotocin-Induced Diabetic Rats

Shuling Wang, Jing Zhang

Int. J. Pharmacol. 2022, 18(4), 753-764; https://doi.org/10.3923/ijp.2022.753.764

Abstract

Download

Goniothalamin Suppressed Glioblastoma Cell Proliferation Through p38 MAPK Phosphorylation Mediated Apoptosis

Open Access Research Article

Goniothalamin Suppressed Glioblastoma Cell Proliferation Through p38 MAPK Phosphorylation Mediated Apoptosis

Rentao Li, Lei Zhao, Sandhanasamy Devanesan, Murali Kannan Maruthamuthu, Yu Yin

Int. J. Pharmacol. 2022, 18(4), 746-752; https://doi.org/10.3923/ijp.2022.746.752

Abstract

Download

Efavirenz nanoemulsion: Formulation Optimization by Box-Behnken Design, in vivo Pharmacokinetic Evaluation and Stability Assessment

Open Access Research Article

Efavirenz nanoemulsion: Formulation Optimization by Box-Behnken Design, in vivo Pharmacokinetic Evaluation and Stability Assessment

Sabna Kotta, Abdul Wadood Khan, Shahid H. Ansari, Rakesh Kumar Sharma, Y.T. Kamal, Hibah Mubarak Aldawsari, Nabil Abdulhafiz Alhakamy, Sanjula Baboota, Javed Ali

Int. J. Pharmacol. 2022, 18(4), 732-745; https://doi.org/10.3923/ijp.2022.732.745

Abstract

Download

156

LAMB1 Promotes Nasopharyngeal Carcinoma Cell Growth and Motility

Open Access Research Article

LAMB1 Promotes Nasopharyngeal Carcinoma Cell Growth and Motility

Jinqiao Huang

Int. J. Pharmacol. 2022, 18(4), 721-731; https://doi.org/10.3923/ijp.2022.721.731

Abstract

Download

First-Line Treatment After the Failure of Androgen Deprivation Therapy for Non-Metastatic, Castration-Resistant Prostate Cancer Men

Open Access Research Article

First-Line Treatment After the Failure of Androgen Deprivation Therapy for Non-Metastatic, Castration-Resistant Prostate Cancer Men

Yuhong Zhu, Gaojie Yang, Yangyang Ding, Lifen Wu

Int. J. Pharmacol. 2022, 18(4), 714-720; https://doi.org/10.3923/ijp.2022.714.720

Abstract

Download

Investigation of Colistin and Polymyxin B on Clinical Extreme Resistant Enterobacteriaceae Isolates for Surveillance Purposes

Open Access Research Article

Investigation of Colistin and Polymyxin B on Clinical Extreme Resistant Enterobacteriaceae Isolates for Surveillance Purposes

Promise Madu Emeka, Lorina Ineta Badger-Emeka, Edric Estrella, Glenda Belgira Angeles, Hany Ezzat Khalil Ahmed

Int. J. Pharmacol. 2022, 18(4), 699-713; https://doi.org/10.3923/ijp.2022.699.713

Abstract

Download

133

Siomycin A Induces Cytotoxicity in Gastric Cancer Cells by Targeting AKT/FOXM1 Axis

Open Access Research Article

Siomycin A Induces Cytotoxicity in Gastric Cancer Cells by Targeting AKT/FOXM1 Axis

Junling Chen, Xia Yu, Baoguo Xu

Int. J. Pharmacol. 2022, 18(4), 691-698; https://doi.org/10.3923/ijp.2022.691.698

Abstract

Download

Prednisone Combined with Antiviral Agents for the Treatment of Early Idiopathic Brachial Plexus Neuritis: Report of 5 Cases

Open Access Research Article

Prednisone Combined with Antiviral Agents for the Treatment of Early Idiopathic Brachial Plexus Neuritis: Report of 5 Cases

Xueyuan Li, Miao Yu, Miaozhong Li, Kyaw Thura, Xiaoling Zhou, Hong Chen

Int. J. Pharmacol. 2022, 18(4), 682-690; https://doi.org/10.3923/ijp.2022.682.690

Abstract

Acute Toxicity Studies and Psychopharmacological Effects of Eucalyptus globulus Leaf Oil in Rodents

Open Access Research Article

Acute Toxicity Studies and Psychopharmacological Effects of Eucalyptus globulus Leaf Oil in Rodents

Muhammad Afzal, Imran Kazmi, Sami I. Alzarea, K.K. Sharma, Chetan Kumar Dubey, Piyush Mittal, Anurag Verma, Arinjay Jain, Ali Alquraini

Int. J. Pharmacol. 2022, 18(4), 673-681; https://doi.org/10.3923/ijp.2022.673.681

Abstract

Download

151

Effects of Diosmin on IL-1β- Induced Inflammatory Response in Primary Rat Chondrocytes

Open Access Research Article

Effects of Diosmin on IL-1β- Induced Inflammatory Response in Primary Rat Chondrocytes

Chunbiao Wu, Chengwei Lian, Jingjing Sun, Zheng Zhang, Xiaojin Pan

Int. J. Pharmacol. 2022, 18(4), 667-672; https://doi.org/10.3923/ijp.2022.667.672

Abstract

Download

114

Melatonin Plus Sitagliptin Reduces Ischemia/Reperfusion-Induced Myocardial Arrhythmias Through Mitochondrial K-ATP Channels in Obese Rats

Open Access Research Article

Melatonin Plus Sitagliptin Reduces Ischemia/Reperfusion-Induced Myocardial Arrhythmias Through Mitochondrial K-ATP Channels in Obese Rats

Li Wang, Chang Liu

Int. J. Pharmacol. 2022, 18(4), 657-666; https://doi.org/10.3923/ijp.2022.657.666

Abstract

Download

Predictive Analysis of COVID-19 Symptoms with CXR Imaging and Optimize the X-Ray Imaging Using Segmentation Thresholding Algorithm-An Evolutionary Approach for Bio-Medical Diagnosis

Open Access Research Article

Predictive Analysis of COVID-19 Symptoms with CXR Imaging and Optimize the X-Ray Imaging Using Segmentation Thresholding Algorithm-An Evolutionary Approach for Bio-Medical Diagnosis

N. Prabhakaran, S. Anandha Prasad, M. Kamali, C. Sabarinathan, I. Chandra, V. Prabhu

Int. J. Pharmacol. 2022, 18(4), 644-656; https://doi.org/10.3923/ijp.2022.644.656

Abstract

Download

Deubiquitylating Enzyme OTUB2 Promotes the Progress of Liver Cancer Cells by Stabilizing TRIM54

Open Access Research Article

Deubiquitylating Enzyme OTUB2 Promotes the Progress of Liver Cancer Cells by Stabilizing TRIM54

An Wang, Xiaofeng Chen, Dongen Li, Liang Yang, Jianshuai Jiang

Int. J. Pharmacol. 2022, 18(4), 633-643; https://doi.org/10.3923/ijp.2022.633.643

Abstract

Download

Enhanced Bioavailability of Epigallocatechin Gallate (EGCG) after Esterification and Complexation with Fish Oil

Open Access Research Article

Enhanced Bioavailability of Epigallocatechin Gallate (EGCG) after Esterification and Complexation with Fish Oil

Sheng-Chang Lin, Hui-Fang Chiu, Yun-Chen Hsieh, Kamesh Venkatakrishnan, Oksana Golovinskaia, Chin-Kun Wang

Int. J. Pharmacol. 2022, 18(4), 623-632; https://doi.org/10.3923/ijp.2022.623.632

Abstract

Download

190

102

Antimicrobial Activity of Tamarind Seeds Extract on Pseudomonas aeruginosa Biofilm Forming Isolates

Open Access Research Article

Antimicrobial Activity of Tamarind Seeds Extract on Pseudomonas aeruginosa Biofilm Forming Isolates

WeamIzzeldin Kamil, Hind Haidar Ahmed, Ahmed Ibrahim Hashim Elhaj Ismail, Tariq-E. Elmissbah, Haytham Dahlawi

Int. J. Pharmacol. 2022, 18(4), 618-622; https://doi.org/10.3923/ijp.2022.618.622

Abstract

Download

163

Formulation and Development of Prednisolone Loaded Nanoparticulate Injection for the Treatment of Arthritis

Open Access Research Article

Formulation and Development of Prednisolone Loaded Nanoparticulate Injection for the Treatment of Arthritis

Shen Yue, Lv Bo

Int. J. Pharmacol. 2022, 18(4), 611-617; https://doi.org/10.3923/ijp.2022.611.617

Abstract

Download

Dipsacus asperoides Extract Improves Physiological Behaviour and Controls Oxidative Stress Produced by a Rat Model of Osteoarthritis

Open Access Research Article

Dipsacus asperoides Extract Improves Physiological Behaviour and Controls Oxidative Stress Produced by a Rat Model of Osteoarthritis

Yingbin Wu, Yue Chen, Zheng Xu, Ming Xiang

Int. J. Pharmacol. 2022, 18(4), 598-610; https://doi.org/10.3923/ijp.2022.598.610

Abstract

Download

112