NRF2 and Cancer

Dear Colleagues,

Nuclear factor erythroid 2-related factor 2 (NRF2) is a critical transcription factor that regulates cellular antioxidant systems in response to oxidative stress. Interestingly, in recent years, accumulating evidence has suggested that Nrf2 may play a dual role in cancer, either in cancer prevention or cancer progression. Thus, aberrant activation of Nrf2 is associated with a poor prognosis; the constitutive activation of Nrf2 in various cancers induces pro‐survival genes and promotes cancer cell proliferation. More importantly, Nrf2 contributes to the chemo- and radioresistance of cancer cells as well as inflammation‐induced carcinogenesis. Notably, NRF2 plays a central role in cancer progression, not only because of its antioxidant activity but also because it establishes cross-talk with several oncogenic pathways including heat shock factor 1, mammalian target of rapamycin, and mutant p53. For these reasons, Nrf2 has emerged as a possible anticancer therapeutic target.

This special issue will include reviews and research articles on the topic, “NRF2 and cancer.” It will gather the latest knowledge on the molecular mechanisms of NRF2 activation in cancer and the development of NRF2 inhibitors to be used to improve chemo- and radiotherapy in cancer treatment.

Assoc. Prof. Dr. Gabriella D’Orazi
Guest Editor

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2600 USD. Submitted manuscripts should be well formatted in good English.