Background: In this study, we analyzed intestinal
flora in an experimental mouse model of chronic kidney disease (CKD) and
investigated whether oral supplementation with probiotic Lactobacillus
rhamnosus GG could slow the decline in renal function and inflammatory status of
mice with CKD. Methods: We surgically induced chronic
kidney disease in C57BL/6J male mice aged 8–9 weeks. We used dual-stage 5/6
nephrectomy for this, while the mock group underwent a mock procedure. The
experimental (CKD mice) and mock group were administered a daily dose of 10