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†These authors contributed equally.
Background: The occurrence and development of chronic obstructive
pulmonary disease (COPD) are regulated by environmental and genetic factors. In
hypoxia, Erythropoietin (EPO) satisfies the body’s need for oxygen by
promoting the production of red blood cells. Hypoxia was proven to be a common
physiological condition in COPD progression and associated with many
complications. Some studies have found that EPO is involved in the
development of COPD. But the mechanism has not been fully proven.
Methods: We conducted a case-control study enrolled 1095 COPD patients
and 1144 healthy controls in Guangdong Province to evaluate the association
between EPO polymorphisms (rs1617640 A