- Academic Editor
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†These authors contributed equally.
Background: Dexmedetomidine (DEX) reportedly protects against
ischemia-reperfusion (I/R) injury and associated damage to the kidneys, but the
underlying mechanisms have yet to be established. Methods: Unilateral
nephrectomy was performed in Wistar rats, and the remaining kidney was clamped
for 1 h prior to reperfusion to establish an experimental model system. These
animals were then randomized into Sham, DEX + Sham, DEX + I/R, ATI (Altepamizole,