- Academic Editor
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Background: Whether gonadotropin-releasing hormone agonist (GnRH-a)
pituitary suppression improves clinical outcomes in non-endometriosis patients
undergoing frozen embryo transfer remains controversial. The objective of this
study is to investigate whether GnRHa combined with hormone replacement treatment
(HRT) compared to HRT alone can improve the clinical outcomes of frozen-thawed
embryo transfer in patients without endometriosis. Methods: This is a
retrospective cohort study. This study involved 2178 frozen-thawed embryo
transfer (FET) cycles of non-endometriosis patients between January 2018 and
December 2019, of these cycles, 1535 were GnRHa-HRT combined cycles and 643 were
HRT alone cycles. The primary outcomes were the clinical pregnancy and live birth
rates. SPSS software (version 23.0, IBM Corp., Chicago, IL, USA) was
used for data analysis. Results: Single-factor analysis showed
that the live birth and implantation rates -were higher in the GnRHa-HRT group
than those in the HRT group (p