Background: Pre-eclampsia is a serious disorder associated with
pregnancy, but its etiology remains poorly understood. In this study, we aimed to
explore the shared genes and molecular pathways between pre-eclampsia and type 2
diabetes mellitus (T2DM). Methods: The record of 2160 pregnant women who
had pre-eclampsia risk assessed by placental growth factor (PIGF) levels in
Fuyang People’s Hospital, China were retrospectively reviewed. The microarray
datasets of pre-eclampsia and T2DM were searched in the Gene Expression Omnibus
(GEO) and were downloaded for secondary analysis. Results: According to
the PIGF stratification, the high-risk group had a significantly higher
proportion of T2DM than the low-risk group (51/326, 15.6% vs. 1.4%,
p
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Open Access
Original Research
Exploration of the Shared Genes and Molecular Pathways between Pre-Eclampsia and Type 2 Diabetes Mellitus via Co-Expression Networks Analysis
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1
Department of Obstetrics, Fuyang People’s Hospital, 236006 Fuyang, Anhui, China
*Correspondence: dzf1180@163.com (Zhifang Ding)
Clin. Exp. Obstet. Gynecol. 2023, 50(4), 73;
https://doi.org/10.31083/j.ceog5004073
Submitted: 15 December 2022 | Revised: 11 January 2023 | Accepted: 29 January 2023 | Published: 14 April 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
pre-eclampsia
type 2 diabetes mellitus
KEGG
PI3K-Akt
Figures
Fig. 1.