- Academic Editor
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†These authors contributed equally.
Background: To evaluate whether the
addition of human menopausal gonadotropin (HMG) during the early follicular phase
of controlled ovarian stimulation improves clinical outcomes in patients
classified as group 4 on the Patient-Oriented Strategy Encompassing
IndividualizeD Oocyte Number (POSEIDON) classification. Methods: A
prospective, randomized, and non-blind controlled trial was conducted, involving
172 patients seeking infertility treatment with an indication for in vitro
fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Among them, 78
patients were randomly assigned to the HMG/follicle stimulating hormone (FSH)
group, receiving 75 IU of HMG for FSH on either day 2 or day 3 of menstruation,
while 94 patients were assigned to the FSH monotherapy group. Results:
The total dose of gonadotropin used in the HMG/FSH group (2510.77