Academic Editor: Andrea Tinelli
Background:
The vulvar lichen simplex chronicus (VLSC) is a common condition in gynecologic
clinics. Though VLSC is not life-threatening, it usually causes pruritus,
soreness and dispareunia, which cause general discomfort. The exact etiology of
VLSC is unclear. This study was performed to explore the vaginal microbiota of
VLSC and to identify the possible microbial
factors in attacks. Methods: Ninety women were recruited. 45 patients
with VLSC and 45 women without vulvar symptom were identified as lichen simplex
chronicus (LSC) and H groups respectively. The vaginal microbiota of the two arms
were compared by the V3-V4 region of 16S rRNA sequencing. Results: The
LSC group had less alpha diversity than H group (p