IMR Press / CEOG / Volume 49 / Issue 8 / DOI: 10.31083/j.ceog4908188
Open Access Review
Molecular Signature of Gynecological Malignancies: A Narrative Review
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1 Department of Pathology, Faculty of Medicine, King Abdulaziz University and King Abdulaziz University Hospital, 21589 Jeddah, Saudi Arabia
*Correspondence: SNSaharti@kau.edu.sa (Samah Saharti)
Academic Editor: Michael H. Dahan
Clin. Exp. Obstet. Gynecol. 2022, 49(8), 188; https://doi.org/10.31083/j.ceog4908188
Submitted: 21 March 2022 | Revised: 19 July 2022 | Accepted: 27 July 2022 | Published: 8 August 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: Cancer research is significantly improved by comprehensive DNA sequencing and profiling. Genes involved in diagnostic, prognostic, or therapeutic consequences have been extensively studied using high-throughput sequencing. Thus, precision medicine based on cancer genotype has been developed, leading to improved survival. The fifth edition of the World Health Organization Classification of Tumors specified a diagnostic molecular pathology section under each disease category. Methods: We highlight the molecular aspects in research and diagnostics of diverse gynecological malignancies using database resources in addition to data mining software tools. Results: This review article presents insight into various gynecological cancers and their different characteristics, offering better profiling for switching to better therapeutic options. Conclusions: Genomic profiling is evolving as a clinically feasible tool for personalizing treatment. It can provide insight regarding treatment plans for common gynecological cancers.

Keywords
molecular markers
gynecological malignancies
hereditary cancer syndrome
Figures
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