Academic Editor: Michael H. Dahan
Background: Ovarian torsion is an important gynecological emergency and
various agents are used in the experimental phase to prevent ovarian injury. The aim of this study was to determine the effect of granulocyte-colony-stimulating factor (G-CSF) use on ischemia/reperfusion injury in torsion/detorsion model of rat ovary.
Methods: Twenty-eight Wistar-albino rats were randomly divided into four
groups. The first group was designated as the sham group, and torsion/detorsion
was applied to the remaining three groups. The third group was given saline and
the fourth group was given G-CSF before detorsion. The total antioxidant and
oxidant status, oxidative stress index, catalase, malondialdehyde and total thiol
values were measured in rat ovaries, and after torsion/detorsion the follicles
numbers of rat ovary were determined by histopathological examination.
Results: There was no significant difference between groups in oxidative
stress markers. However, the primary and secondary follicle numbers in the G-CSF
group were significantly higher than the other torsion/detorsion groups