IMR Press / CEOG / Volume 49 / Issue 7 / DOI: 10.31083/j.ceog4907161
Open Access Case Report
A hepatitis B virus flare that led to hepatic decompensation and liver transplantation in a pregnant woman with chronic hepatitis B: a rare case report and literature review
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1 Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, 114 Taipei, Taiwan
2 Department of Obstetrics and Gynecology, Hoima Regional Referral Hospital, 7272 Hoima, Uganda
*Correspondence: jacky90621@gmail.com (Chuang-Yen Huang)
Academic Editor: Michael H. Dahan
Clin. Exp. Obstet. Gynecol. 2022, 49(7), 161; https://doi.org/10.31083/j.ceog4907161
Submitted: 10 August 2021 | Revised: 13 September 2021 | Accepted: 22 September 2021 | Published: 12 July 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: Acute viral hepatitis is the most common cause of jaundice during pregnancy. Distinct immunological changes during pregnancy and the postpartum period are possible crucial factors associated with flares of chronic hepatitis B. Case: We present the case of a healthy pregnant hepatitis B virus (HBV) carrier at 38 weeks of gestation. She underwent an emergent cesarean section due to acute hepatitis B flare, and ultimately underwent liver transplantation due to a decompensating liver based on an estimated Model for End-Stage Liver Disease score. Conclusions: For pregnant HBsAg positive women, close monitoring with serum HBV-DNA and spartate transaminase (AST)/alanine transaminase (ALT) levels every 3 months is highly recommended. According to the latest guidelines, prenatal antiviral therapy, postpartum HBV vaccination, and hepatitis B immunoglobulin should be administered to prevent mother-to-child transmission.

Keywords
Case report
Hepatitis B
Liver transplantation
Pregnancy
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